長寿医療の最前線　　歯周病病因論の新しいパラダイムを求めて

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  • 松下 健二
    国立長寿医療センター研究所 口腔疾患研究部

書誌事項

タイトル別名
  • A New Paradigm of Etiology of Periodontal Diseases
  • シシュウビョウ ビョウインロン ノ アタラシイ パラダイム オ モトメテ

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抄録

Periodontal disease is a disorder that affects about 80% of Japanese adults. However, the etiology has not been fully elucidated. Periodontal disease is considered a disorder in which the host-parasite relationship is most important for the etiology. However, the importance of systemic factors and environmental factors, such as aging and lifestyle habits, in the etiology of periodontal disease has not been clarified. Not only impairments of vasculature and gingival tissue by aging and accumulation of lifestyle habit but also evolution of vascular inflammation and blood coagulation by periodontopathic bacteria Porphyromonas gingivalis are involved in the etiology. Gingipains, which are trypsin-like proteinases produced by P. gingivalis, activate several blood coagulation factors such as factor X. Activated factor X (FXa) and gingipains induce expressions of proinflammatory cytokines and matrix metalloproteases and then evoke vascular inflammation and blood coagulation, both locally and systemically. The immune-pathological activity of periodontopathic bacteria is important for considering periodontal disease as a systemic disease. In addition, regulation of the protease cascade activated by P. gingivalis gingipains may be a new strategy for treatment of periodontal disease.

収録刊行物

  • 医療

    医療 60 (12), 764-772, 2006

    一般社団法人 国立医療学会

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