Zeolite 4A, a Synthetic Silicate, Suppresses Melanogenesis through the Degradation of Microphthalmia-Associated Transcription Factor by Extracellular Signal-Regulated Kinase Activation in B16F10 Melanoma Cells

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  • Shin Yong Jae
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
  • Han Chang-Soo
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
  • Lee Chang Seok
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
  • Kim Hong-Sook
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
  • Ko Seong-Hee
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
  • Hwang Seung Kyun
    Greenjui
  • Ko Seong-Gyu
    Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
  • Shin Jong Wook
    Department of Internal Medicine, Chung Ang University College of Medicine
  • Ye Sang-Kyu
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
  • Chung Myung-Hee
    Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University

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Zeolite 4A, synthetic silicate, has been shown to exhibit diverse biological activities such as anti-cancer and anti-oxidant activity. In the present study, we report that the zeolite 4A may improve skin-whitening. We found that zeolite 4A inhibited melanin production in a dose-dependent manner, which has not cytotoxicity. Zeolite 4A also inhibited alpha-melanocyte-stimulating hormone (α-MSH)-induced melanin synthesis in B16F10 cells. Interestingly, zeolite 4A decreased α-MSH-induced tyrosinase activity in B16F10 cells, which did not inhibit tyrosinase activity under cell-free conditions. The results of this study indicate that zeolite 4A may reduce pigmentation by way of an indirect nonenzymatic mechanism. We also found that zeolite 4A decreased α-MSH-induced microphthalmia-associated transcription factor (MITF) and tyrosinase expression and that zeolite 4A induced the activation of extracellular signal-regulated kinase (ERK). These results suggest that the depigmenting effect of zeolite 4A may result from the down-regulation of MITF and tyrosinase expression by increasing ERK activity. The results thus provide evidence that zeolite 4A can be used as a potential skin-whitening agent.

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