非定型下痢原性大腸菌について 1

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  • 涌嶋 三津子
    公立大学法人 大阪市立大学 大学院生活科学研究科
  • 王 麗麗
    公立大学法人 大阪市立大学 大学院生活科学研究科
  • 日高 あゆみ
    公立大学法人 大阪市立大学 大学院生活科学研究科
  • 藤原 佐美
    公立大学法人 大阪市立大学 大学院生活科学研究科
  • 中島 涼
    公立大学法人 大阪市立大学 大学院生活科学研究科
  • 石 娟娟
    公立大学法人 大阪市立大学 大学院生活科学研究科
  • 西川 禎一
    公立大学法人 大阪市立大学 大学院生活科学研究科

書誌事項

タイトル別名
  • A Typical Diarrheagenic <I>Escherichia coli</I> Part 1
  • 非定型下痢原性大腸菌について(1)腸管凝集接着性大腸菌耐熱性腸管毒素(EAST1)遺伝子保有大腸菌
  • ヒテイケイ ゲリ ゲンセイ ダイチョウキン ニ ツイテ 1 チョウカン ギョウシュウ セッチャクセイ ダイチョウキン タイネツセイ チョウカン ドクソ EAST1 イデンシ ホユウ ダイチョウキン
  • ―腸管凝集接着性大腸菌耐熱性腸管毒素（EAST1）遺伝子保有大腸菌―
  • —Enteroaggregative <I>E. coli</I> heat-stable toxin 1 (EAST1) gene-possessing <I>E. coli</I>—

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抄録

Escherichia coli is a normal inhabitant of the intestinal tract in humans and warm-blooded animals; however, certain strains cause enteric disease in their hosts and are referred to as diarrheagenic E. coli (DEC). Based on distinct epidemiological and clinical features, specific virulence determinants, and other characteristic markers such as enterotoxins and adherence phenotype, DEC strains have been classified into the following six pathotypes: enteropathogenic E. coli; Shiga toxin-producing E. coli; enterotoxigenic E. coli (ETEC); enteroinvasive E. coli; enteroaggregative E. coli (EAEC); and diffusely adhering E. coli. E. coli that does not have any diarrheagenic characteristics other than the EAEC heat-stable toxin 1 (EAST1) gene is defined as EASTEC. Although EAST1 has not been widely accepted as a virulence factor, we focused our attention on EASTEC because outbreaks due to EASTEC O166:H15 have occurred in several cities since the first incident in Osaka, Japan, in 1996. In the present review, we discuss EASTEC as a possible seventh group of DEC. Guanylin is secreted in the colon and acts physiologically as an agonist of the guanylyl cyclase receptor to regulate electrolyte and water transport in the epithelia. EAST1, like the heat-stable enterotoxins of ETEC, may mimic guanylin and cause diarrhea. However, epidemiological studies show that the EAST1 gene (astA) is very prevalent not only among EASTEC strains from diarrheal patients but also in healthy people, domestic animals, and meat products. The presence of astA itself may therefore not necessarily indicate that the strain will be diarrheagenic in the intestine. Production of active EAST1 should be checked since astA seems to have numerous variants. The development of a convenient assay for EAST1 is essential. Further epidemiological studies are also required to elucidate whether EASTEC forms a seventh group of DEC; such studies would also identify additional virulence traits such as colonization factor.

収録刊行物

  • 生活衛生

    生活衛生 54 (4), 271-284, 2010

    社団法人 大阪生活衛生協会

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