A Proposed Method for Administration of Dithiazanine Iodide in Enteric Coated Tablets

DOI Web Site

Bibliographic Information

Other Title
  • 犬におけるヨウ化ジチアザニン腸溶錠の投与法について
  • イヌ ニ オケル ヨウカ ジチアザニン チョウ ヨウジョウ ノ トウヨホウ ニ ツイテ

Search this article

Abstract

Dithiazanine iodide in enteric coated tablets induces no vomiting after administration. It has been supplied since 1964 as a worming drug for whipworms, microfilariae of Dirofilaria immitis, hookworms, and ascarids in canine practice. It is usual that one tablet per 5kg of body weight of the dog is given per os, without fasting, once a day for 3 to 5 consecutive days. It is found, however, that the worming rate of the tablet is lower than the conventional method.<BR>Forty dogs were observed 2 to 72 hours after administration of the tablet (a tablet per 5kg of body weight per os) at noon between morning (8 A.M.) and evening (5 P.M.). It was found that the lower worming rate was caused by an individual differencein the moving of the tablet from stomach to small intestine.<BR>In other 40 dogs, the tablet was given at noon to dogs fasted during the morning, or 29 hours after the feeding. The individual difference decreased. The worming rate was higher than that in those given the tablet between the morning and evening feeding, with no fasting. In this experiment, 20mg/kg (for 2 days) and 4 mg/kg (for 5 days) of dithiazanine iodide were administered. Twenty mg/kg (2 days) gave rise to some ill-effects, such as adecrease in appetite.<BR>Accordingly, the present method should be changed to the administration of 1 tablet per 5kg of body weight of the dog at noon every day for dogs fasted during the morning for 3 to 5 consecutive days.

Journal

Details 詳細情報について

Report a problem

Back to top