Microangiophatic Hemolytic Anemia (MHA) in a Patient with Dissiminated Gastric Carcinoma

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  • KAWAMURA Setsuko
    The 1st Department of Internal Medicine Hirosaki University School of Medicine
  • OKAWA Motohiro
    The 1st Department of Internal Medicine Hirosaki University School of Medicine
  • YOSHIDA Yutaka
    The 1st Department of Internal Medicine Hirosaki University School of Medicine
  • SASAKI Akira
    Institute of Cerebrovascular Accidents Hirosaki University

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Other Title
  • 広汎な胃癌転移にみられたmicroangiopathic hemolytic anemiaの1例
  • コウハン ナ イガン テンイ ニ ミラレタ microangiopathic hemolytic anemia ノ 1レイ

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Abstract

A 25-year-old man was transferred to our department from a local hospital on December 15, 1967 for diagnostic examinations for anemia and lumbago.<br>The patient was well until August 1967 when fatigue and cardiac parpitation were noted more than expected with a mountain climb. The patient, however, did not see a physician until December 7, when the symptoms mentioned above became gradually worse in addition to recent development of lumbago. Anemia of RBC 225×104, Hb 45% (Sahli) was found, and the patient was transferred to our department.<br>Physical examination on admission was essentially negative except for generalized anemic appearance. Spleen and lymphnodes were not palpable. A marked anemia of hemoglobin 5.49 g/100 ml and a prolongation of plasma clot time were seen.<br>Bone marrow aspiration was dry tap, and a hemolytic anemia was diagnosed with a high plasma hemoglobin level of 769 mg/100 ml. Blood transfusion caused an elevation of body temperature up to 38°C and did not increase hemoglobin volume as calculated. The patient died on the 15th hospital day, and the autopsy revealed a small carcinoma at the cardia of the stomach with a dissiminated metastasis to the liver, spleen, bone marrow, and others. Microangiopathy with massive tumor thrombi was found in the lungs and kidneys.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 10 (1), 76-82, 1969

    The Japanese Society of Hematology

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