Studies of the Chemotherapy of Leprosy

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  • KIM JYUNG MYUNG
    Department of Clinical Pathology, Medical School Kyungpuck University
  • KOHSAKA KENJI
    Department of Leprology, Research Institute for Microbial Diseases, Osaka University
  • YAMAGUCHI MIYOKO
    Department of Leprology, Research Institute for Microbial Diseases, Osaka University
  • NISHIMURA SHINJI
    Department of Leprology, Research Institute for Microbial Diseases, Osaka University

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Other Title
  • 癩の化学療法に関する研究
  • 癩の化学療法に関する研究-24-Ethambutol,Capreomycin sulfateの鼠癩発症に及ぼす影響
  • ライ ノ カガク リョウホウ ニ カンスル ケンキュウ 24 Ethambutol , Capreomycin sulfate ノ ネズミライハッショウ ニ オヨボス エイキョウ
  • (XXIV) Effect of Ethambutol, Capreomycin sulfate on the Development of Murine Leprosy
  • (第24報)Ethambutol, Capreomycin sulfateの鼠癩発症に及ぼす影響

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Abstract

The effect of anti-tubercular agents Ethambutol (d-2, 2'-(ethylene diimino)-di-1-butanol 2Hl; Ebutol, Kaken) and Capreomycin sulfate (Capastat, Shionogi) on the development of murine leprosy was investigated.<br>Method: A total of 100 female mice (ddO) were inoculated subcutaneously with a suspension of Hawaiian strain, and Ethambutol(10mg, oral) or Capreomycin sulfate (0.5mg, intramuscular) given by the 6 days per week method. The control was left untreated or give INH, or Streptomycin. The inhibitory effect was evaluated by both of the Nishimura-Iwasa's method and the observation of spread tissue specimens from the subcutaneous connective tissue where the bacilli had been inoculated, at weekly intervals up to 5 weeks after the inoculation.<br>Results: Both examination methods showed that Ethambutol and Capreomycin sulfate not suppressed murine leprosy. The spread tissue method gave highly accurate results and were well coincident with the results by the Nishimura-Iwasa's method suggesting that this is a useful method for screening using murine leprosy.

Journal

  • Repura

    Repura 37 (3), 229-232, 1968-09-30

    JAPANESE LEPROSY ASSOCIATION

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