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- Yoshida Toshio
- Department of Pediatrics Faculty of Medicine, Tohoku University
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- Tada Keiya
- Department of Pediatrics Faculty of Medicine, Tohoku University
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- Yokoyama Yoshimasa
- Department of Pediatrics Faculty of Medicine, Tohoku University
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- Arakawa Tsuneo
- Department of Pediatrics Faculty of Medicine, Tohoku University
書誌事項
- タイトル別名
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- Homocystinuria of Vitamin B<sub>6</sub> Dependent Type
この論文をさがす
抄録
In three patients with homocystinuria, an intramuscular injection of vitamin Bs was done and its effect was investigated clinically and biochemically.<br> In only one of the patients, the vitamin B6 administration brought about almost complete disappearance of urinary homocystine and an in vitro study on cystathionine synthetase activity of the liver revealed that the enzyme activity was activated when an excess of pyridoxal phosphate was added to the assay system. In the remaining two patients with homocystinuria, no beneficial effect was ob-served clinically and biochemically by treatment with pyridoxal phosphate. In one of them an in vitro study of the enzyme assay of the liver was done, showing that the enzyme activity was not influenced by addition of an excess of pyridoxal phosphate to the assay system.<br> These findings suggest that there are two types of homocystinuria, one being vitamin Bs dependent and the other not dependent on vitamin B6.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 96 (3), 235-242, 1968
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204243278720
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- NII論文ID
- 130003408654
- 40018682753
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- NII書誌ID
- AA00863920
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- COI
- 1:STN:280:DyaF1M7lt1OnsA%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 8507793
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- PubMed
- 5717883
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可