書誌事項
- タイトル別名
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- A Case with Severe Combined Immunodeficiency Diagnosed with Disseminated BCG Infection
- 症例 RD遺伝子の特異的欠如の検出により播種性BCG感染症と診断した重症複合型免疫不全症の1例
- ショウレイ RD イデンシ ノ トクイテキ ケツジョ ノ ケンシュツ ニ ヨリ ハシュセイ BCG カンセンショウ ト シンダン シタ ジュウショウ フクゴウガタ メンエキ フゼンショウ ノ 1レイ
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Because the Bacillus Calmette-Guérin (BCG) prevents infants from contracting miliary tuberculosis and tuberculosis meningitis, BCG vaccination is recommended for those under 6 months old in Japan. Complications such as favorable local inflammatory reactions including redness, induration, and abscess formation may occur, but severe adverse effects such as osteomyelitis, periostitis, and disseminated BCG infection are generally rare. We report an 11-month-old boy with severe combined immunodeficiency dying of serious disseminated BCG infection despite anti-tuberculosis therapy and blood stem cell transplantation. He was vaccinated with disseminated BCG infection at 4 months before severe combined immunodeficiency diagnosis was confirmed by specific RD gene deletion based on allele-specific polymerase chain reaction. Although BCG is considered safe, we should keep in mind that subjects with immunological deficiency may suffer severe BCG complications.
収録刊行物
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- 感染症学雑誌
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感染症学雑誌 85 (2), 176-179, 2011
一般社団法人 日本感染症学会
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詳細情報 詳細情報について
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- CRID
- 1390001205050400896
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- NII論文ID
- 10029687726
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- NII書誌ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL書誌ID
- 11070774
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可