Parasitology: Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages
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- NISHIKAWA Yoshifumi
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
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- IBRAHIM Hany M.
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Zoology Department, Faculty of Science, Minufiya University
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- KAMEYAMA Kyohko
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
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- SHIGA Ikumi
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
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- HIASA Jun
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
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- XUAN Xuenan
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
書誌事項
- タイトル別名
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- Host Cholesterol Synthesis Contributes to Growth of Intracellular Toxoplasma gondii in Macrophages
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抄録
The intracellular protozoan Toxoplasma gondii lacks the ability to synthesize sterol and scavenges cholesterol from the low-density lipoprotein receptor (LDLR) pathway of its host to facilitate replication. Sterol biosynthesis inhibitors, however, have a demonstrated anti-Toxoplasma effect. In this study, we examined the host mevalonate pathway as a novel source of cholesterol for T. gondii and its effects on parasite growth in macrophages. Parasite growth did not significantly change in the absence of LDLR or when LDL was exogenously supplemented. Lovastatin and compactin, both inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase in the mevalonate pathway, significantly inhibited T. gondii growth in both wild-type and LDLR-knockout macrophages. Parasite growth was also suppressed by squalestatin, an inhibitor of squalene synthase, despite mevalonate producing isoprenoid intermediates in host cells. The present study demonstrates that lovastatin, compactin and squalestatin have anti-Toxoplasma activities and that the host cholesterol synthesis may contribute to parasite growth in macrophages.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 73 (5), 633-639, 2011
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681406613248
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- NII論文ID
- 120006390574
- 130000444791
- 40018864926
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 11133335
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可