Laboratory animal science: Prevalence of murine norovirus infection in Korean laboratory animal facilities

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  • KIM Jong Rhan
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University Biomedical Research Institute, Seoul National University Hospital
  • SEOK Seung Hyeok
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • KIM Dong Jae
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • BAEK Min-Won
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • NA Yi-Rang
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • HAN Ju-Hee
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • KIM Tae-Hyun
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • PARK Jae-Hak
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • TURNER Patricia V.
    Department of Pathology, Ontario Veterinary College, University of Guelph
  • CHUNG Doo Hyun
    Biomedical Research Institute, Seoul National University Hospital
  • KANG Byeong-Cheol
    Biomedical Research Institute, Seoul National University Hospital Graduate School of Immunology, College of Medicine, Seoul National University

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タイトル別名
  • Prevalence of Murine Norovirus Infection in Korean Laboratory Animal Facilities

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抄録

Currently, murine noroviruses (MNV) are the most prevalent viral pathogens identified in laboratory animal facilities. While several reports exist concerning the prevalence of MNV in North American research facilities, very few reports are available for other parts of the world, including Korea. This study evaluated the prevalence of MNV infection in 745 murine sera collected from 15 animal facilities in Korea by enzyme linked immunosorbent assay (ELISA). Positive cases were subcategorized by murine strain/genetics, housing environments and animal sources. In summary, 6.6% of inbred/outbred mice purchased from commercial vendors were seropositive, 9.6% of in-house colonies were seropositive and 27.0% of genetically modified mice (GMM) were seropositive. Partial gene amplification of fecal isolates from infected animals showed that they were homologous (100%) with MNV-4.<br>

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