Sasa quelpaertensis Phenylpropanoid Derivative Suppresses Lipopolysaccharide-induced Nitric Oxide Synthase and Cyclo-oxygenase-2 Expressions in RAW 264.7 Cells
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- MOON Ji-Young
- Bio-Convergence Center Department of Chemistry, Jeju National University
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- YANG Eun-Jin
- Bio-Convergence Center
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- KIM Sang Suk
- Department of Chemistry, Jeju National University
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- KANG Ji-Yong
- Bio-Convergence Center
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- KIM Gi-Ok
- Bio-Convergence Center
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- LEE Nam Ho
- Department of Chemistry, Jeju National University
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- HYUN Chang-Gu
- Bio-Convergence Center
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3-O-p-Coumaroyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-O-β-D-gulcopyranosylpropanol (ESQ10) is a naturally occurring phenylpropanoid derivative isolated from Sasa quelpaertensis (Gramineae). In the present study, we discovered that ESQ10 inhibits nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. ESQ10 attenuated LPS-induced synthesis of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in parallel and inhibited LPS-induced interleukin-6 production, as determined by an enzyme-linked immunosorbent assay in the macrophages. The mechanism of the antiinflammatory action of ESQ10, i.e., suppression of nuclear factor (NF)-κB and mitogen-activated protein kinase activation, has been documented. However, ESQ10 could not influence LPS-mediated IκB-α degradation and extracellular signal-regulated kinase/c-Jun amino-terminal kinase phosphorylation at concentrations of up to 373 μM. To test the potential application of ESQ10 as a topical material, we also conducted a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human HaCaT keratinocytes as well as human dermal fibroblast cells. In this assay, ESQ10 did not induce cytotoxicity. Taken together, the results suggest that ESQ10 may be considered an antiinflammatory candidate for treating inflammatory and skin diseases.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 131 (6), 961-967, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206129649024
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- NII論文ID
- 130000926982
- 40018874087
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 11143457
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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