甲状腺腫蕩組織における転写抑制因子PLZFの発現パターンについての検討

機関リポジトリ Web Site

書誌事項

タイトル別名
  • Transcriptional repressor PLZF is differentially expressed in thyroid neoplasm，reflecting the impairment of follicular formation
  • 甲状腺腫瘍組織における転写抑制因子PLZFの発現パターンについての検討
  • コウジョウセン シュヨウ ソシキ ニ オケル テンシャ ヨクセイ インシ PLZF ノ ハツゲン パターン ニ ツイテ ノ ケントウ

この論文をさがす

抄録

PLZF (Promyelocytic Leukemia Zn Finger) is a transcriptional repressor which is originally isolated from a patient with promyelocytic leukemia. Moreover, PLZF affects the key element of cell cycle progression such as cyclin A. So far, the functional role of PLZF in thyroid cells remains unclear. In this study, we analyzed the expression profile of PLZF in thyroid neoplasms. We estimated PLZF expression in normal thyroid (n=6), multinodular goiter (n=4), follicular adenoma (n=3), follicular carcinoma (n=1), papillary carcinoma (n=18) and anaplastic carcinoma (n=3). PLZF expression was estimated by immunohistochemical staining and western blotting. In all of papillary carcinoma, PLZF is expressed in cytosol with high intensity. In contrast, in normal thyroid, follicular adenoma and follicular carcinoma, P LZF is localized in nucleus. We speculate that the intracellular translocation of PLZF reflects the differentiation between benign and malignancy. Although follicular carcinoma is malignant tissue, its PLZF expression pattern was same as benign thyroid tissues. Then differentiation of PLZF expression in follicular carcinoma from papillary carcinoma and anaplastic carcinoma is due to retaining follicular structure. We presume that PLZF expression in nucleus could be related to the maintenance of follicular structure.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ