Dose-Response Effects of an Aqueous Formulation of Calcitriol and Evaluation of Renal Function in Nonpregnant Cows

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  • KIM Danil
    United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
  • YAMAGISHI Norio
    United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
  • KAWAKAMI Yuji
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
  • ABE Izumi
    Nippon Zenyaku Kogyo Co., Ltd., Fukushima 963-0196, Japan
  • FURUHAMA Kazuhisa
    United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
  • DEVKOTA Bhuminand
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan Institute of Agriculture and Animal Science, Tribhuvan University, Chitwan, Nepal
  • SASAKI Kouya
    United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
  • OKURA Norimoto
    Biei Veterinary Clinical Center, Kamikawa Chuo Agricultural Mutual Aid Association, Hokkaido 071-0200, Japan
  • SATO Shigeru
    United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan
  • OHASHI Shuichi
    Nippon Zenyaku Kogyo Co., Ltd., Fukushima 963-0196, Japan

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Dose responses of plasma calcitriol, calcium (Ca), bone metabolic markers and glomerular filtration rate (GFR) were evaluated in four nonpregnant Holstein cows treated subcutaneously with an aqueous formulation of calcitriol at four doses in a 4 × 4 Latin-square design. Calcitriol, Ca, and markers of bone metabolism were analyzed in plasma samples. GFR was measured in predose and day 5 samples. Plasma calcitriol and Ca concentrations increased dose-dependently. The calcitriol dose was positively correlated with the area under the concentration-time curve of plasma calcitriol. Bone formation markers tended to increase from day 3 onward for all doses. No significant changes in GFR were noted. Thus, exogenous calcitriol administered between 0.0625 and 0.5 μg/kg body weight elicited dose-dependent increases in both plasma calcitriol and Ca and elevated bone formation markers without affecting renal function in nonpregnant cows.

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