Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice

• KIM Tae-Won

  College of Veterinary Medicine, Chungnam National University

• LIM Jong-Hwan

  B&C Biopharm, Advanced Institutes of Convergence Technology

• SONG In-Bae

  College of Veterinary Medicine, Chungnam National University

• PARK Sang-Jin

  B&C Biopharm, Advanced Institutes of Convergence Technology

• YANG Jae-Won

  B&C Biopharm, Advanced Institutes of Convergence Technology

• SHIN Jung Cheul

  B&C Biopharm, Advanced Institutes of Convergence Technology

• SUH Joo-Won

  Division of Bioscience and Bioinformatics, Myongji University

• SON Hwa-Young

  College of Veterinary Medicine, Chungnam National University

• CHO Eun-Sang

  College of Veterinary Medicine, Chungnam National University

• KIM Myoung-Seok

  Jeollanamdo Development Institute for Traditional Korean Medicine

• LEE Sang-Wook

  B&C Biopharm, Advanced Institutes of Convergence Technology

• KIM Jong-Woo

  B&C Biopharm, Advanced Institutes of Convergence Technology

• YUN Hyo-In

  College of Veterinary Medicine, Chungnam National University

書誌事項

タイトル別名

• Hepatoprotective and Anti-Hepatitis C Viral Activity of <i>Platycodon grandiflorum</i> Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice

抄録

The present study aims to evaluate the anti-HCV activity of hotwater extract from Platycodon grandiflorum (BC703) with HCV genotype 1b subgenomic replicon system and investigate its hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in mice. BC703 produced significant hepatoprotective effects against CCl₄-induced acute hepatic injury by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation. Histopathological studies further substantiated the protective effect of BC703. Furthermore, BC703 inhibited the HCV RNA replication with an EC₅₀ value and selective index (CC₅₀/EC₅₀) of 2.82 μg/mL and above 35.46, respectively. However, digested BC703 using a simulated gastric juice showed poor protective effect against CCl₄-induced hepatotoxicity in mice and decreased anti-HCV activity as compared to the intact BC703. Although further studies are necessary, BC703 may be a beneficial agent for the management of acute hepatic injury and chronic HCV infection.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 58 (3), 187-194, 2012

  一般財団法人 学会誌刊行センター

キーワード

• <i>Platycodon grandilorum</i>
• carbon tetrachloride
• hepatotoxicity
• hepatitis C virus

詳細情報

• CRID: 1390001206324259072
• NII論文ID: 130002103043
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.58.187
• COI: 1:CAS:528:DC%2BC38XhtVegt7%2FO
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 023768190
• PubMed: 22878389
• Web Site: http://id.ndl.go.jp/bib/023768190
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023768190
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可