Jacaric Acid, a Linolenic Acid Isomer with a Conjugated Triene System, Reduces Stearoyl-CoA Desaturase Expression in Liver of Mice

• Shinohara Nahoko

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Ito Junya

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Tsuduki Tsuyoshi

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Honma Taro

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Kijima Ryo

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Sugawara Soko

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Arai Tatsuya

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Yamasaki Masao

  Department of Biochemistry and Applied Biosciences, University of Miyazaki

• Ikezaki Aya

  Department of Biochemistry and Applied Biosciences, University of Miyazaki

• Yokoyama Marino

  Department of Biochemistry and Applied Biosciences, University of Miyazaki

• Nishiyama Kazuo

  Department of Biochemistry and Applied Biosciences, University of Miyazaki

• Nakagawa Kiyotaka

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agriculture, Tohoku University

• Miyazawa Teruo

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agriculture, Tohoku University

• Ikeda Ikuo

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

抄録

Conjugated fatty acid is a collective term used for fatty acids with conjugated double bond systems. Seed oils from certain plants include conjugated linolenic acids, which have a conjugated triene system and are geometrical and positional isomers of α-linolenic acid. One of these isomers, jacaric acid (JA, 8c, 10t, 12c-18:3), has not been examined widely. Therefore, we investigated the absorption and metabolism of JA in normal animals (ICR mice). An oral dose of JA of 5 mg/day for 1 week had no effects on body weight, food intake and tissue weight of mice. JA was detected in the serum, kidney, liver, lung and epididymal white adipose tissue. Analysis of the fatty acid composition in liver and white adipose tissue showed a tendency to increase levels of saturated fatty acids (SFAs) such as palmitic acid (16:0) and stearic acid (18:0) and to decrease levels of monounsaturated fatty acids (MUFAs) such as palmitoleic acid (16:1) and oleic acid (18:1). Thus, JA treatment decreased the desaturation index (16:1/16:0, 18:1/18:0) in liver and white adipose tissue. This index is used as an indicator of the activity of stearoyl coenzyme A desaturase (SCD), an endoplasmic reticulum enzyme that catalyzes the biosynthesis of MUFAs from SFAs. The change in this index indicates that JA inhibited SCD activity in ICR mice, and further experiments showed that JA also decreased the expression level of SCD-1 mRNA. Inhibition of SCD activity may have anti-obesity and anti-diabetes effects, and therefore the findings in this study suggest that JA may be effective for preventing obesity and diabetes.

収録刊行物

• Journal of Oleo Science

  Journal of Oleo Science 61 (8), 433-441, 2012

  公益社団法人 日本油化学会

キーワード

• conjugated fatty acid
• conjugated linolenic acid
• Jacaranda seed oil
• jacaric acid
• stearoyl coenzyme A desaturase

詳細情報

• CRID: 1390001204091679744
• NII論文ID: 130004435972
• NII論文ID: 40019348697
• NII書誌ID: AA11503337
• DOI: 10.5650/jos.61.433
• COI: 1:STN:280:DC%2BC38flsF2jug%3D%3D
• ISSN: 13473352
• ISSN: 13458957
• NDL書誌ID: 023824022
• PubMed: 22864514
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023824022
• Web Site: https://www.jstage.jst.go.jp/article/jos/61/8/61_433/_pdf
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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