光電容積脈波式血中アルコール濃度計測装置の開発—<i>in vivo</i>試験による予備的検討—

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  • A Preliminary Study on Development of a Novel Optical Instrument for Non-invasive Blood Alcohol Measurement:Proposal of Pulse Alcometry
  • 光電容積脈波式血中アルコール濃度計測装置の開発 : in vivo試験による予備的検討
  • コウデン ヨウセキ ミャクハシキ ケッチュウ アルコール ノウド ケイソク ソウチ ノ カイハツ : in vivo シケン ニ ヨル ヨビテキ ケントウ

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In this preliminary study, we examined in human volunteers the performance of the developed prototype device for non-invasive quantification of blood alcohol concentration (BAC) by near-infrared light which is highly transparent to the body. We aimed at applying the results to the final goal of developing a novel alcohol-based vehicle ignition-interlock device. Accumulating evidence shows that one of the ethyl alcohol absorption peaks in the near-infrared region is present at 1,185 nm. We combined this with our recent development of a non-invasive optical method for blood glucose measurement, which we call pulse glucometry, using blood volume pulsations in a finger within a cardiac cycle. Thus, we developed a novel method, pulse alcometry, for non-invasive measurement of BAC. We calculated second derivative values of optical density (ODλ”) to remove baseline over a band including three wavelengths, 1,150 nm, 1,185 nm, and 1,220 nm. Then, a simple linear regression analysis was performed with the measured ODλ” to predict BAC levels. In 3 healthy male volunteers, during alcohol intake and washout, periodic optical measurements using the present device were made simultaneously with collection of blood samples for in vitro BAC analysis. In leave-one-out cross validations within an individual, the measured BAC and the predicted BAC correlated well (r = 0.773∼0.846, mean absolute error = 0.134∼0.333mg/ml). We conclude that, from the results of this preliminary study, the new method appears to be able to estimate BAC levels non-invasively. However, further investigations in a larger group of subjects will be needed in order to determine fully the operational performance of this new measurement system.

収録刊行物

  • 生体医工学

    生体医工学 50 (2), 237-247, 2012

    公益社団法人 日本生体医工学会

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