光電容積脈波式血中アルコール濃度計測装置の開発 : in vivo試験による予備的検討 A Preliminary Study on Development of a Novel Optical Instrument for Non-invasive Blood Alcohol Measurement : Proposal of Pulse Alcometry

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In this preliminary study, we examined in human volunteers the performance of the developed prototype device for non-invasive quantification of blood alcohol concentration (BAC) by near-infrared light which is highly transparent to the body. We aimed at applying the results to the final goal of developing a novel alcohol-based vehicle ignition-interlock device. Accumulating evidence shows that one of the ethyl alcohol absorption peaks in the near-infrared region is present at 1,185 nm. We combined this with our recent development of a non-invasive optical method for blood glucose measurement, which we call pulse glucometry, using blood volume pulsations in a finger within a cardiac cycle. Thus, we developed a novel method, pulse alcometry, for non-invasive measurement of BAC. We calculated second derivative values of optical density (OD λ") to remove baseline over a band including three wavelengths, 1,150 nm, 1,185 nm, and 1,220 nm. Then, a simple linear regression analysis was performed with the measured OD λ" to predict BAC levels. In 3 healthy male volunteers, during alcohol intake and washout, periodic optical measurements using the present device were made simultaneously with collection of blood samples for in vitro BAC analysis. In leave-one-out cross validations within an individual, the measured BAC and the predicted BAC correlated well (r = 0.773~0.846, mean absolute error = 0.134~0.333mg/ml). We conclude that, from the results of this preliminary study, the new method appears to be able to estimate BAC levels non-invasively. However, further investigations in a larger group of subjects will be needed in order to determine fully the operational performance of this new measurement system.

収録刊行物

  • 生体医工学

    生体医工学 50(2), 237-247, 2012-04

    Japanese Society for Medical and Biological Engineering = 日本生体医工学会 JSMBE

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各種コード

  • NII論文ID(NAID)
    40019356725
  • NII書誌ID(NCID)
    AA11633569
  • 本文言語コード
    JPN
  • 資料種別
    Journal Article
  • ISSN
    1347-443X
  • NDL 記事登録ID
    023838577
  • NDL 請求記号
    Z19-108
  • データ提供元
    CJP引用  NDL  IR 
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