Involvement of the skeletal rennin-angiotensin system in age-related osteoporosis of aged mice

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  • GU Sa-sa
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology Center for Systems Biomedical Science, University of Shanghai for Science and Technology
  • ZHANG Yan
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology Center for Systems Biomedical Science, University of Shanghai for Science and Technology
  • LI Xiao-li
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology Center for Systems Biomedical Science, University of Shanghai for Science and Technology
  • WU Shu-yan
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology Center for Systems Biomedical Science, University of Shanghai for Science and Technology
  • DIAO Teng-yue
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology Center for Systems Biomedical Science, University of Shanghai for Science and Technology
  • HAI Rong
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology Center for Systems Biomedical Science, University of Shanghai for Science and Technology
  • DENG Hong-wen
    Center for Systems Biomedical Science, University of Shanghai for Science and Technology School of Public Health and Tropical Medicine, Tulane University Center for Systems Biomedical Science, University of Shanghai for Science and Technology School of Public Health and Tropical Medicine, Tulane University

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タイトル別名
  • Involvement of the Skeletal Renin-Angiotensin System in Age-Related Osteoporosis of Ageing Mice

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The local tissue-specific renin-angiotensin system (RAS) was identified. The aim of this study was to investigate the role of local bone RAS in the osteoporosis of aging mice. Twelve-month-old and two-month-old male mice were respectively assigned to the ageing and young groups. The tibias and femurs were collected for an analysis of histomorphology, bone mass, and gene and protein expression. H&E staining and micro-CT measurement showed a loss of the trabecular bone network and decrease of bone mineral density in the proximal tibial metaphysis of the aged mice. The PCR results indicated the significant up-regulation of renin and angiotensinogen (AGT) mRNA expression in both the tibia and femur of the ageing mice. Western blotting data showed that the tibial angiotensin II protein expression was significantly increased in the ageing group. The enhancement of renin and AGT expression in the bone tissue resulted in the increased production of angiotensin II which plays an important role in the pathology of age-related osteoporosis.

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