The Effect of Submicron Emulsion Systems on Transdermal Delivery of Kaempferol

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  • Chao Yun
    School of Pharmacy, Kaohsiung Medical University
  • Huang Chi-Te
    School of Pharmacy, Kaohsiung Medical University
  • Fu Li-Tse
    School of Pharmacy, Kaohsiung Medical University
  • Huang Yaw-Bin
    Graduate Institute of Clinical Pharmacy, Kaohsiung Medical University
  • Tsai Yi-Hung
    Graduate Institute of Clinical Pharmacy, Kaohsiung Medical University
  • Wu Pao-Chu
    School of Pharmacy, Kaohsiung Medical University

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In this study, submicron emulsions have been employed as a carrier for the topical application of kaempferol. The effect of components of submicron emulsions on the physicochemical properties and permeation capability of drug were evaluated. In case of drug-loaded submicron emulsions, the cumulative amount over 12 h (Q12 h), lag time and deposition in skin amount ranged from 13.0±3.4 to 236.1±21.2 µg/cm2, 1.7 to 5.3 h, and 1.10 to 7.76 µg/cm2, respectively, which indicated that the permeation parameters of kaempferol were markedly influenced by the component ratio. Kaempferol dispensed in isopropyl myristate was used as the control. The Q12 h, lag time and deposition amount in skin were 4.2±1.8 µg/cm2, 6.0 h and 2.25±0.60 µg/cm2, respectively. The data showed that used appropriate submicron emulsions as vehicle could significantly increase the Q12 h and deposition amount in skin and shorten the lag time, demonstrating that submicron emulsions have a potent enhancement effect for kaempferol transdermal delivery.

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