光駆動性陽イオンチャネルであるチャネルロドプシンの結晶構造

• 加藤 英明

  東京大学大学院理学系研究科

• 濡木 理

  東京大学大学院理学系研究科

書誌事項

タイトル別名

• Crystal Structure of Channelrhodopsin, A Light-Gated Cation Channel
• ヒカリ クドウセイ ヨウ イオンチャネル デ アル チャネルロドプシン ノ ケッショウ コウゾウ

抄録

Channelrhodopsin (ChR) is a light-gated cation channel derived from algae that conducts cations, including sodium ions, in a light-dependent manner. Because the inward flow of sodium ions triggers the neuron firing, neurons expressing ChRs can be optically controlled even within freely moving mammals. Although ChR has been broadly applied to neuroscience research, little is known about its molecular mechanisms. We determined the crystal structure of ChR at 2.3 Å resolution and revealed its molecular architecture, especially, the cation-conducting pathway. The integration of structural and electrophysiological analyses provided insight into the molecular basis for the remarkable function of ChR, and paved the way for the principled design of ChR variants with novel properties.

収録刊行物

• 日本結晶学会誌

  日本結晶学会誌 54 (4), 220-225, 2012

  日本結晶学会

詳細情報

• CRID: 1390282679066949504
• NII論文ID: 10031042484
• NII書誌ID: AN00188364
• DOI: 10.5940/jcrsj.54.220
• ISSN: 18845576
• ISSN: 03694585
• NDL書誌ID: 023970077
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023970077
• 本文言語コード: ja
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可