顎口腔領域における静脈奇形に対するオレイン酸モノエタノールアミンを用いた硬化療法

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  • Intralesional sclerotherapy with ethanolamine oleate for subcutaneous venous malformations in the oral and maxillofacial region
  • ガク コウコウ リョウイキ ニ オケル ジョウミャク キケイ ニ タイスル オレインサン モノエタノールアミン オ モチイタ コウカ リョウホウ

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BACKGROUND: Vascular malformations of the oral and maxillofacial region may stand out, and can cause speech or chewing disorders and bleeding. In addition, in some cases it is difficult to excise the entire lesion and to reconstruct cosmetically, and the remaining lesions may recur. Recently, sclerotherapy has been suggested as the primary treatment for vascular anomalies, instead of surgery. This study examined the effects and complications of sclerotherapy in treating vascular malformations of the oral and maxillofacial region.<br>METHODS: We treated ten vascular malformations in nine patients using sclerotherapy. We used 5% ethanolamine oleate as the sclerosing agent, which is used for the endoscopic treatment of esophageal varices. To confirm the safety of the treatments, the patients were hospitalized during the treatment and the treatments were performed under fluoroscopy and contrast-enhanced computed tomography guidance.<br>RESULTS: Magnetic resonance imaging (MRI) examination after treatment revealed that all of the lesions had improved. Furthermore, seven of the lesions had disappeared. Complications after treatments were pain in six cases and swelling in all ten cases. One patient developed hemoglobinuria, but intravenous haptoglobin protected against renal dysfunction.<br>CONCLUSIONS: Intralesional sclerotherapy of vascular malformations using ethanolamine oleate is an effective treatment, enabling the restoration of cosmesis and function.

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