A Mechanism of Norovirus Pandemic Based on Comprehensive Genome Analysis
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- MOTOMURA Kazushi
- Pathogen Genomics Center, National Institute of Infectious Diseases
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- YOKOYAMA Masaru
- Pathogen Genomics Center, National Institute of Infectious Diseases
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- OKA Tomoichiro
- Department of Virology II, National Institute of Infectious Diseases
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- KATAYAMA Kazuhiko
- Department of Virology II, National Institute of Infectious Diseases
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- NODA Mamoru
- National Institute of Health Sciences
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- TANAKA Tomoyuki
- Sakai city Institute of Public Health
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- SATO Hironori
- Pathogen Genomics Center, National Institute of Infectious Diseases
Bibliographic Information
- Other Title
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- ノロウイルスのゲノム解析と流行発生のしくみ
- 第84回日本感染症学会総会座長推薦論文 ノロウイルスのゲノム解析と流行発生のしくみ
- ダイ84カイ ニホン カンセンショウ ガッカイ ソウカイ ザチョウ スイセン ロンブン ノロウイルス ノ ゲノム カイセキ ト リュウコウ ハッセイ ノ シクミ
- ノロウイルスのゲノム解析と流行発生のしくみ
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Abstract
Norovirus GII.4 is a major etiological agent of acute viral gastroenteritis worldwide. We examined GII.4 evolution using 277 near-full-length GII.4 genome sequences from human stool specimens collected at 20 sites in Japan between May 2006 and March 2010. We found outbreaks of 8 monophyletic GII.4 subtypes,among which a single subtype, termed 2006b, had continually predominated (222/277 : 80.7%). Four of the 8 GII.4 subtypes were chimera viruses of recently prevalent GII.4 subtypes. Notably, single putative recombination breakpoints with the highest statistical significance were constantly located around the border of open reading frame 1 (ORF) 1 and ORF 2 (P<0.0001), suggesting outgrowth of specific recombinant viruses in the outbreaks. The GII.4 subtypes had many unique amino acids at the time of their outbreaks, especially in the N-term, 3A-like, and capsid proteins. Unique amino acids in the capsid were preferentially positioned on the outer surface loops of the protruding P2 domain. These data and computer-assisted structural study of NoV capsid protein are compatible with a model of antigenic drift with tuning of the structure-functions of multiple proteins for the survival strategy of GII.4 2006b variant.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 86 (5), 563-568, 2012
The Japanese Association for Infectious Diseases
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Keywords
Details 詳細情報について
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- CRID
- 1390282680025069696
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- NII Article ID
- 130004642450
- 10031144078
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- NII Book ID
- AN00047715
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- COI
- 1:STN:280:DC%2BC3s7nvVyrsg%3D%3D
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 023986521
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- PubMed
- 23198575
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed