連続再評価法とその周辺（I）—連続再評価法とは—

• 大門 貴志

  兵庫医科大学医学部数学教室

書誌事項

タイトル別名

• The Continual Reassessment Method (CRM) and Related Topics—A Review. Part I: Understanding the CRM for Dose-Finding Studies.
• 連続再評価法とその周辺(1)連続再評価法とは
• レンゾク サイヒョウカホウ ト ソノ シュウヘン(1)レンゾク サイヒョウカホウ トワ
• The Continual Reassessment Method (CRM) and Related Topics^|^mdash;A Review. Part I: Understanding the CRM for Dose-Finding Studies.

抄録

A number of designs of phase I dose-finding trials have been developed. Algorithm-based designs such as standard 3 + 3 designs are easy to understand and implement since they do not require explicit model specification for a dose-toxicity relationship. On the other hand, model-based designs such as the continual reassessment method (CRM) (O’Quigley et al., 1990) have been proposed. The author will give a review of the CRM and its related topics. In particular, the author makes mention of some of the problems with 3 + 3 designs that have often been used in phase I dose-finding studies and gives a detailed description of ideas, concepts, theories, properties and issues in the CRM.

収録刊行物

• 計量生物学

  計量生物学 33 (1), 1-29, 2012

  日本計量生物学会

キーワード

• clinical trials
• cancer clinical trials
• oncology trials
• phase I trials
• phase I/II trials
• maximum tolerated dose
• dose finding
• dose escalation
• model-based de-signs
• algorithm-based designs
• safety
• toxicity
• efficacy

詳細情報

• CRID: 1390282679345300224
• NII論文ID: 130002151415
• NII書誌ID: AA11591618
• DOI: 10.5691/jjb.33.1
• ISSN: 21856494
• ISSN: 09184430
• NDL書誌ID: 023998640
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023998640
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可