連続再評価法とその周辺（II）—連続再評価法の修正・拡張版と関連デザイン—

• 大門 貴志

  兵庫医科大学医学部数学教室

書誌事項

タイトル別名

• The Continual Reassessment Method (CRM) and Related Topics—A Review. Part II: Modified/Extended CRMs and Related Designs.
• 連続再評価法とその周辺(2)連続再評価法の修正・拡張版と関連デザイン
• レンゾク サイヒョウカホウ ト ソノ シュウヘン(2)レンゾク サイヒョウカホウ ノ シュウセイ ・ カクチョウバン ト カンレン デザイン
• The Continual Reassessment Method (CRM) and Related Topics^|^mdash;A Review. Part II: Modified/Extended CRMs and Related Designs.

抄録

During the last two decades there have been many methodological developments in the design and analysis of phase I, phase II and phase I/II dose-finding studies. Much of these developments originate from the continual reassessment method (CRM), which has gained popularity since its first proposal by O’Quigley et al. (1990). In this paper the author will give a review of the CRM and its related topics. In particular, the author takes a general view of dose-finding and -escalation designs that are extended from or related to the CRM, providing a brief bibliographical introduction of them.

収録刊行物

• 計量生物学

  計量生物学 33 (1), 31-76, 2012

  日本計量生物学会

キーワード

• clinical trials
• cancer clinical trials
• oncology trials
• phase I trials
• phase I/II trials
• maximum tolerated dose
• dose finding
• dose escalation
• model-based designs
• algorithm-based designs
• safety
• toxicity
• efficacy

詳細情報

• CRID: 1390282679345307136
• NII論文ID: 130002151416
• NII書誌ID: AA11591618
• DOI: 10.5691/jjb.33.31
• ISSN: 21856494
• ISSN: 09184430
• NDL書誌ID: 023998659
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023998659
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可