Exposure to Multiwalled Carbon Nanotubes and Allergen Promotes Early- and Late-Phase Increases in Airway Resistance in Mice
-
- Mizutani Nobuaki
- Department of Pharmacology, Kobe Pharmaceutical University
-
- Nabe Takeshi
- Department of Pharmacology, Kyoto Pharmaceutical University
-
- Yoshino Shin
- Department of Pharmacology, Kobe Pharmaceutical University
この論文をさがす
抄録
The facilitating effects of multiwalled carbon nanotubes (MWCNT) on allergic asthma have not been sufficiently examined, although MWCNT appear to significantly increase the risk of health problems from occupational or environmental exposure. In this study, we examined whether sensitization by the combination of MWCNT with ovalbumin (OVA) promotes allergic asthmatic responses. BALB/c mice administered vehicle, MWCNT, OVA, or MWCNT+OVA through an intranasal route were challenged with OVA intratracheally four times. In the MWCNT+OVA group, the fourth challenge caused not only early- but also late-phase increases in airway resistance, although these responses were not observed in the vehicle, MWCNT, or OVA group; furthermore, the extents of the early and late responses were comparable to those in mice systemically sensitized with OVA+alum. Sensitization with MWCNT and OVA promoted airway inflammation and goblet cell hyperplasia in the lung compared with the vehicle, MWCNT or OVA group. In addition, adjuvant activity for OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a production in serum and increased levels of interleukin-4 (IL-4), IL-5, IL-13, and IL-17 in the lung tissue were observed. In conclusion, these results suggest that exposure to MWCNT and antigen can induce a biphasic increase in airway resistance, airway inflammation, goblet cell hyperplasia, and the production of antigen-specific antibodies. This study highlights the risk of exposure to a combination of MWCNT with antigen.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 35 (12), 2133-2140, 2012
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679610367104
-
- NII論文ID
- 130002480502
-
- NII書誌ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC3s7oslOltw%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 024105591
-
- PubMed
- 23207765
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可