Freeze-Dried Royal Jelly Maintains Its Developmental and Physiological Bioactivity in Drosophila melanogaster
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- KAYASHIMA Yasunari
- School of Food and Nutritional Sciences, University of Shizuoka School of Food and Nutritional Sciences, University of Shizuoka
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- YAMANASHI Keiko
- School of Food and Nutritional Sciences, University of Shizuoka School of Food and Nutritional Sciences, University of Shizuoka
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- SATO Ayaka
- School of Food and Nutritional Sciences, University of Shizuoka School of Food and Nutritional Sciences, University of Shizuoka
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- KUMAZAWA Shigenori
- School of Food and Nutritional Sciences, University of Shizuoka School of Food and Nutritional Sciences, University of Shizuoka
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- YAMAKAWA-KOBAYASHI Kimiko
- School of Food and Nutritional Sciences, University of Shizuoka School of Food and Nutritional Sciences, University of Shizuoka
書誌事項
- タイトル別名
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- Freeze-Dried Royal Jelly Maintains Its Developmental and Physiological Bioactivity in <i>Drosophila melanogaster</i>
- Freeze-dried royal jelly maintains its developmental and physiological bioactivitiy in Drosophila melanogaster
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抄録
Royal jelly (RJ), a honeybee-derived product, has been found to possess developmental and physiological bioactivity in the fruit fly, Drosophila melanogaster, but little is known about the in vivo bioactivity of freeze-dried RJ (FDRJ) powder, which is another form of RJ processed for human use. To address this, we used Drosophila as a model animal to examine the effects of FDRJ in multicellular organisms. When flies were reared on food supplemented with FDRJ, the developmental time from larva to adult was shortened, the adult male lifespan was prolonged, and female fecundity was increased without any significant morphological alterations. Moreover, the expression of dilp5, an insulin-like peptide, its receptor InR, and the nutrient sensing molecule TOR, the target of rapamycin, was significantly increased in FDRJ-fed female flies as compared with ones reared on standard and on protein-enriched food. These findings suggest that like RJ, FDRJ maintains its bioactivity even after processing from RJ, what is expected to have bioactivity for multicellular organisms, including humans.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 76 (11), 2107-2111, 2012
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206477742976
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- NII論文ID
- 130004137860
- 10031126516
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3s7hsV2nuw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024108001
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- PubMed
- 23132575
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可