中心子のマジックナンバー「9」の決定機構

• 廣野 雅文

  東京大学大学院理学系研究科

書誌事項

タイトル別名

• Mechanism for the Establishment of Nine-ness, the Magic Number of Centrioles
• チュウシンコ ノ マジックナンバー 「 9 」 ノ ケッテイ キコウ

抄録

Centrioles are cell organelles consisting of nine triplet microtubules arranged in rotational symmetry. This structure is highly conserved among various eukaryotic organisms and serves as the template for the “9 + 2” or “9 + 0” structures of ciliary axonemes. How this nine-fold symmetrical structure forms is a long-standing question. Recently, genetic approaches using Chlamydomonas revealed that the cartwheel, a sub-centriolar structure with a hub and nine spokes, plays a pivotal role in the establishment of nine-fold symmetry, and that a protein called SAS-6 is a key component of the cartwheel assembly. This review summarizes the Chlamydomonas studies and recent advances in the understanding the SAS-6 function.<br>

収録刊行物

• 生物物理

  生物物理 52 (6), 272-277, 2012

  一般社団法人 日本生物物理学会

キーワード

• Centriole
• basal body
• ciliary axoneme
• <i>Chlamydomonas</i>
• SAS-6
• Bld10p

詳細情報

• CRID: 1390001206533958912
• NII論文ID: 10031126099
• NII書誌ID: AN00129693
• DOI: 10.2142/biophys.52.272
• COI: 1:CAS:528:DC%2BC38XhslOhsbrK
• ISSN: 13474219
• ISSN: 05824052
• NDL書誌ID: 024108445
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024108445
• Web Site: https://www.jstage.jst.go.jp/article/biophys/52/6/52_272/_pdf
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可