5-FUに起因した高アンモニア血症をきたした舌癌の1例

• 土肥 豊

• 越路 千佳子

• 泉 さや香

• 麻野 和宏

• 川又 均

• 今井 裕

書誌事項

タイトル別名

• A case of a tongue cancer associated with hyperammonemia caused by 5-fluorouracil
• 5-FU ニ キイン シタ コウアンモニア ケツショウ オ キタシタ ゼツガン ノ 1レイ

抄録

We describe a patient with tongue cancer who had hyperammonemia with impaired consciousness possibly caused by 5-fluorouracil (5-FU). <br>The patient, a 72-year-old-man, was given a diagnosis of tongue squamous cell carcinoma (T₄N_2cM₀). He underwent subtotal tongue resection and bilateral neck dissection, followed immediately by reconstructive surgery with a rectus abdominis muscle flap. As postoperative adjuvant chemotherapy, a regimen of TPF was started, but 2 days later, nausea and vomiting developed, which made oral intake difficult. Six days after treatment began, he experienced disturbance of consciousness. Because of respiratory arrest during cerebral computed tomography (CT) to assess these symptoms, the patient was transferred to the intensive care unit. <br>On CT, no structural abnormalities of the brain were noted; however, blood testing revealed a high NH3 level of 536μg/dL. With intravenous fluid therapy, the NH₃ gradually decreased, the level of consciousness improved, and the NH₃ returned to within normal limits. On the basis of the treatment course and absence of liver dysfunction, the hyperammonemia was attributed to 5-FU.However, 4 months after surgery, the atient had an unexpected outcome due to pulmonary metastasis.

収録刊行物

• 日本口腔外科学会雑誌

  日本口腔外科学会雑誌 58 (11), 646-650, 2012

  社団法人 日本口腔外科学会

キーワード

• 口腔癌
• 5-フルオロウラシル
• 高アンモニア血症
• 意識障害

詳細情報

• CRID: 1390282681509152128
• NII論文ID: 10031144957
• NII書誌ID: AN00189163
• DOI: 10.5794/jjoms.58.646
• ISSN: 21861579
• ISSN: 00215163
• NDL書誌ID: 024108584
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024108584
• Web Site: https://search.jamas.or.jp/link/ui/2013098861
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可