A Case of Bowenoid Papulosis Successfully Treated by Topical Imiquimod Cream

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  • KASE Kimi
    Department of Dermatology, Sapporo Medical University School of Medicine
  • OKURA Masae
    Department of Dermatology, Sapporo Medical University School of Medicine
  • YAMASHITA Toshiharu
    Department of Dermatology, Sapporo Medical University School of Medicine

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Other Title
  • 5 ％イミキモドクリームで加療したボーエン様丘疹症の 1 例
  • 症例 5%イミキモドクリームで加療したボーエン様丘疹症の1例
  • ショウレイ 5%イミキモドクリーム デ カリョウ シタ ボーエン ヨウ キュウシンショウ ノ 1レイ

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Abstract

A 24-year-old Japanese woman was referred to our Dermatology Department due to blackish-brown, velvety surface papules and plaques in the minor and major labia of her genitalia. The gynecological examination found no female genital disorders. The patient had no history of sexually transmitted infection, immunological suppression or steroid ingestion. A punch biopsy was taken from her right major labium. Microscopic examination disclosed an acanthotic epidermis composed of dense keratinocytes with conspicuous cytological atypia and mitotic figures. DNA was extracted from the paraffin section and processed for LI-consensus PCR. An amplified band contained sequences identical to the East-Asian type HPV16. It was subsequently diagnosed as bowenoid papulosis associated with HPV16. The patient was treated by topical imiquimod cream 5% three times a week for five weeks. After the treatment, the lesion was clinically cleared. There were no side effects other than a burning sensation which was not severe enough to merit discontinuing treatment. Five months posttreatment, the patient had not had a recurrence of bowenoid papulosis. This result suggests that imiquimod therapy may be considered an effective treatment for bowenoid papulosis.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 74 (6), 619-622, 2012

    Western Division of Japanese Dermatological Association

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