Protective Effects of Shichimotsu-koka-To on Irreversible Thy-1 Nephritis
-
- Ono Takahiko
- Division of Nephrology, Department of Internal Medicine, Atami Hospital, Intenational University of Health and Welfare Department of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
-
- Kamikado Kohei
- Department of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
-
- Morimoto Tatsuya
- Department of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
この論文をさがす
抄録
Oxidative stress and peritubular capillary (PTC) injury are involved in the progression of chronic kidney disease (CKD). We investigated protective effects of Shichimotsu-koka-To (SKT), a Japanese traditional Kampo prescription, against nephrosclerosis and hypertension on a CKD model due to irreversible nephritis. Six-week-old male Wistar rats were subjected to uninephrectomy, and to injection of rabbit anti-thymocyte serum. SKT treatment was continued for 15 weeks, blood pressure was measured, and then renal specimens were collected. PTC networks were detected by immunostaining for CD-31. And superoxide dismutase (SOD)-like activity in the tissue was evaluated. Blood pressure in the SKT group, as well as sham group, was significantly lower than with the vehicle. SKT markedly ameliorated renal function, which was evaluated with urea nitrogen clearance. Compared with the vehicle, SKT treatment lowered both the glomerular enlargement and hyper-cellularity by 80%, and decreased the extracellular matrix area by 75%. SKT treatment also suppressed tubular injury, and maintained PTC networks. Furthermore, SKT recovered SOD-like activity to the basal levels. These results suggest that SKT may be useful for the treatment of CKD during the progression to nephrosclerosis, through the mechanisms of anti-oxidative activity and maintenance of PTC networks.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 36 (1), 41-47, 2013
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204634248576
-
- NII論文ID
- 130001869766
- 40019536009
-
- NII書誌ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC3s7hsVSjtg%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 024173394
-
- PubMed
- 23131611
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可