How is digit identity determined during limb development?

• Takayuki Suzuki

抄録

Digit identity has been studied using the chick embryo as a model system for more than 40 years. Using this model system, several milestone findings have been reported, such as the apical ectodermal ridge (<jats:styled-content style="fixed-case">AER ), the zone of polarizing activity (<jats:styled-content style="fixed-case">ZPA ), the Shh gene, and the theory of morphogen and positional information. These experimental results and models provided context for understanding pattern formation in developmental biology. The focus of this review is on the determination of digit identity during limb development. First, the history of studies on digit identity determination is described, followed by descriptions of the molecular mechanisms and current models for determination of digit identity. Finally, future questions and remarkable points will be discussed.

収録刊行物

• Development, growth & differentiation

  Development, growth & differentiation 55 (1), 130-138, 2013-01

  Kobe : Japanese Society of Developmental Biologists ; 1969-2014

キーワード

• chick
• digit identity
• Interdigit
• limb
• phalanx forming region
• SHH signaling
• zone of polarizing activity

詳細情報

• CRID: 1520853832158109056
• NII論文ID: 40019549295
• NII書誌ID: AA00627804
• ISSN: 00121592
• ISSN: 1440169X
• DOI: 10.1111/dgd.12022
• NDL書誌ID: 024202959
• Web Site: http://id.ndl.go.jp/bib/024202959
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024202959
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fdgd.12022
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/dgd.12022
• Web Site: https://search.jamas.or.jp/link/ui/2014070011
• 本文言語コード: en
• NDL 雑誌分類:
  • ZR2(科学技術--生物学--生化学)
• データソース種別:
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN