One Pot Synthesis and Biological Activity Evaluation of Novel Schiff Bases Derived from 2-Hydrazinyl-1,3,4-thiadiazole

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  • Haj Mohammad Ebrahim Tehrani Kamaleddin
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
  • Sardari Soroush
    Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute
  • Mashayekhi Vida
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
  • Esfahani Zadeh Marjan
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
  • Azerang Parisa
    Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute
  • Kobarfard Farzad
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences

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Considering the structural features of a group of known potent inhibitors of human platelet aggregation containing hydrazone structural backbone, a series of novel hydrazone derivatives of 2-hydrazinyl-1,3,4-thiadiazole were synthesized using a one-pot process and tested for their inhibitory activity against platelet aggregation induced by arachidonic acid and ADP. Among the derivatives, compounds 3l, 3o and 3p exhibited the highest antiplatelet aggregation activity. The derivatives were also screened for their potential antimycobacterial activity and compounds 3g, 3k, 3p and 3q were among the most active compounds.

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