げっ歯類の脳循環測定から探る脳血流調節機序

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  • Evaluating cerebrovascular regulatory mechanisms using cerebral blood flow measurement technique in rodents.
  • ゲッシルイ ノ ノウ ジュンカン ソクテイ カラ サグル ノウ ケツリュウ チョウセツ キジョ

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In vivo brain imaging techniques such as positron emission tomography and functional magnetic resonance imaging, which are associated with changes in cerebral blood flow (CBF), are widely used for the diagnosis and/or treatment of cerebral vascular impairments and neural disorders. Understanding cerebrovascular regulatory mechanisms is important matter to make effective use of brain imaging techniques in medicine. Animal studies of hemodynamics using rats and mice play an important role in clarifying the regulatory mechanisms of CBF at the microvascular level. Previously, most animal experiments used anesthesia for avoidance of pain and inhibition of motion artifacts caused by movements of the animal. However, anesthesia significantly affects the animal’s physiological condition, for example, by lowering respiratory and cardiac rates along with body temperature. We recently developed a new measuring technique that allows accurate assessment and determination of hemodynamic changes in conscious animals under maintenance of their physiological conditions. In the present paper, we will review the cerebrovascular regulatory mechanisms and discuss these mechanisms as revealed by our new measurement technique.

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