Spectrophotometric Sequential Injection Determination of D-Penicillamine Based on a Complexation Reaction with Nickel Ion

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  • MARTINOVIC-BEVANDA Anita
    Department of Chemistry, Faculty of Science and Education, University of Mostar
  • RADIC Njegomir
    Department of Analytical Chemistry, Faculty of Chemistry and Technology, University of Split

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A simple and sensitive spectrophotometric method, based on reaction between Ni(II) ion and D-penicillamine (PEN), was developed. The proposed SIA system enhanced the analytical applicability of the reaction of complexation, and allowed the determination of PEN in the concentration range of 3.0 × 10−6 – 2.0 × 10−4 mol L−1 with a sampling rate of 200 h−1. With the proposed SIA system, PEN could be accurately determinated up to 0.9 nmol quantity. The method was successfully applied to the determination of PEN in laboratory samples and pharmaceuticals.

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  • Analytical Sciences

    Analytical Sciences 29 (6), 669-671, 2013

    社団法人 日本分析化学会

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