Specific Enhancement of Vascular Endothelial Growth Factor (VEGF) Production in Ischemic Region by Alprostadil : Potential Therapeutic Application in Pharmaceutical Regenerative Medicine
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- Inoue Hajime
- Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Japan Department of Stem Cell Therapy (Endowed Chair by ANGFA Co. Japan), St. Marianna University School of Medicine, Japan
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- Aihara Masaki
- Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Japan
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- Tomioka Miyuki
- Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Japan
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- Watabe Yu-ichi
- Department of Stem Cell Therapy (Endowed Chair by ANGFA Co. Japan), St. Marianna University School of Medicine, Japan
書誌事項
- タイトル別名
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- Specific Enhancement of Vascular Endothelial Growth Factor (VEGF) Production in Ischemic Region by Alprostadil — Potential Therapeutic Application in Pharmaceutical Regenerative Medicine
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抄録
Alprostadil (lipo-PGE1) is a drug delivery system preparation. This preparation is applied to treat refractory skin ulcers and arteriosclerosis obliterans. We investigated the effects of alprostadil by using the earflap ischemic model. The following results were obtained: 1) Treatment with alprostadil significantly increased the VEGF contents in an ischemic ear; 2) Treatment with alprostadil resulted in strongly expressed VEGF levels only in the ischemic region; 3) Image analysis revealed a significant increase in the number of vessel bypasses and paths after flap creation with alprostadil administration compared to the vehicle-treated ears. The results suggest that it may be possible to apply alprostadil as one device for regenerative medical technology.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 122 (2), 158-161, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180975360
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- NII論文ID
- 10031185409
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BC3snoslaluw%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 024638027
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- PubMed
- 23728380
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可