口腔扁平苔癬に対するマレイン酸イルソグラジンの治療効果の検討

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  • Evaluation of therapeutic benefits of Irsogladine maleate for oral lichen planus
  • コウコウ ヘンペイ タイセン ニ タイスル マレインサン イルソグラジン ノ チリョウ コウカ ノ ケントウ

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BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disease and morbidity is 1.2%. Irsogladine maleate (IM) is a drug used for the treatment of gastritis and peptic ulcers. Some reports have shown that IM has been useful for aphthous stomatitis and OLP. However, there are no reports on the clinical response of IM for OLP statistically. This study investigated statistically the therapeutic effect, relevant clinical factors and side effects to clarify the usefulness of IM against OLP.<br>METHODS: The study group consisted of 22 patients who had OLP from January 2007 to October 2010. Irsogladine 2mg × 2/day was administered orally. The end-point of the curative effect was assumed to be “pain”, “number of affected sites”, and “area”, and each of these was scored. Efficacy was evaluated statistically based on the total score pre- and post-administration.<br>RESULTS: The means of the pre-administration scores for “pain”, “number of affected sites” and “area” were statistically different from the post-administration scores. The total post-administration scores correlated with the total pre-administration scores (p = 0.003). The regression equation obtained in the study was (total post-administration score = 0.693×total pre-administration score−1.492). Side effects were not seen in any case.<br>CONCLUSION: IM was safe and effective for patients with OLP.

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