Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

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  • Sari Dina Permata
    Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Andalas
  • Ninomiya Masayuki
    Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University
  • Efdi Mai
    Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Andalas
  • Santoni Adlis
    Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Andalas
  • Ibrahim Sanusi
    Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Andalas
  • Tanaka Kaori
    Division of Anaerobe Research, Life Science Research Center, Gifu University United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University
  • Koketsu Mamoru
    Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University

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  • Clerodane Diterpenes Isolated from <i>Polyalthia longifolia</i> Induce Apoptosis in Human Leukemia HL-60 Cells

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Polyalthia is a versatile genus of shrubs and trees found in tropic and sub-tropic regions. In this study, three clerodane diterpenes, kolavenic acid (1), polyalthialdoic acid (2), and 16α-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (3) isolated from Polyalthia longifolia leaves were evaluated for their apoptotic potential against human leukemia HL-60 cells. Compounds 2 and 3 inhibited cell proliferation with IC50 values of 21.8 and 13.7 μM, respectively. Morphological changes and DNA fragmentation analysis indicated that these diterpenes induce apoptotic cell death in the HL-60 cells. Our results revealed the importance of P. longifolia as a chemopreventive medicinal plant.

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