繊維型大麻草主成分カンナビジオールを基盤としたメディシナルケミストリー

• 竹田 修三

  第一薬科大学

書誌事項

タイトル別名

• Medicinal Chemistry and Pharmacology Focused on Cannabidiol, a Major Component of the Fiber-Type <i>Cannabis</i>
• センイガタ タイマソウ シュセイブン カンナビジオール オ キバン ト シタ メディシナルケミストリー
• Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis

抄録

  Considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, and it has been reported to possess diverse biological activities. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), several studies have investigated whether CBDA itself is biologically active. In the present report, the author summarizes findings indicating that; 1) CBDA is a selective cyclooxygenase-2 (COX-2) inhibitor, and ii) CBDA possesses an anti-migrative potential for highly invasive cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. Further, the author introduces recent findings on the medicinal chemistry and pharmacology of the CBD derivative, CBD-2′,6′-dimethyl ether (CBDD), that exhibits inhibitory activity toward 15-lipoxygenase (15-LOX), an enzyme responsible for the production of oxidized low-density lipoprotein (LDL). These studies establish CBD as both an important experimental tool and as a lead compound for pharmaceutical development. In this review, the author further discusses the potential uses of CBD and its derivatives in future medicines.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 133 (10), 1093-1101, 2013-10-01

  公益社団法人 日本薬学会

キーワード

• fiber-type <i>cannabis</i>
• cannabidiol
• cannabidiolic acid
• cannabidiol-2′,6′-dimethyl ether

詳細情報

• CRID: 1390282681104081792
• NII論文ID: 130004427986
• NII論文ID: 40019820459
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.13-00196
• COI: 1:STN:280:DC%2BC2c%2FlvVWgtg%3D%3D
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 024918872
• PubMed: 24088353
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024918872
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/133/10/133_13-00196/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014024739
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可