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- SUGIBAYASHI Kenji
- Faculty of Pharmaceutical Sciences, Josai University
Bibliographic Information
- Other Title
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- サイエンスとエビデンスに基づく化粧品の研究と開発
- 第38回日本香粧品学会(2013)・会頭講演 サイエンスとエビデンスに基づく化粧品の研究と開発
- ダイ38カイ ニホン コウ ショウヒン ガッカイ(2013)・ カイトウ コウエン サイエンス ト エビデンス ニ モトズク ケショウヒン ノ ケンキュウ ト カイハツ
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Abstract
Usefulness and safety are the most important issues for developing cosmetics and the related quasi-drugs. In addition, they must be scientifically and evidentially evaluated for their valuable and rapid development. Their most important site of actions are cutaneous tissues. Thus, the skin concentration of cosmetic and quasi-drug ingredients must be paid attention, as like in plasma concentration of therapeutic drugs in TDM (therapeutic drug monitoring) and in R&D stages for developing generic drugs. The skin concentration of ingredients topically applied or exposed is closely related to their skin permeations. Thus, a relation between the percutaneous absorption and skin disposition must be important to be theoretically undertaken. In addition, the skin permeation of ingredients in the cosmetics and the quasi-drugs is proportionally related to their thermodynamic activity and greatly affected by use of chemical enhancers and/or physical means to increase the skin permeation such as iontophoresis and microneedles. Their applications must be checked during the development of cosmetics and quasi-drugs. In conclusion, the skin concentration of ingredients is a key for developing good cosmetics and quasi-drugs from scientific and evidential points of view.
Journal
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- JOURNAL OF JAPANESE COSMETIC SCIENCE SOCIETY
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JOURNAL OF JAPANESE COSMETIC SCIENCE SOCIETY 37 (3), 177-180, 2013
Japanese Cosmetic Science Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205512976512
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- NII Article ID
- 130004703402
- 40019838648
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- NII Book ID
- AA12025525
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- ISSN
- 21880719
- 18802532
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- NDL BIB ID
- 024950937
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed