Neurophysiological profile of acoustic startle response in Japanese children with autism spectrum disorders

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  • Takahashi Hidetoshi
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Nakahachi Takayuki
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Moriwaki Aiko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Takei Reiko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Iida Yukako
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Kazuo Ogino
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Kamio Yoko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry

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Other Title
  • 自閉症スペクトラム児の聴覚性驚愕反射に関する神経生理学的検討
  • ジヘイショウ スペクトラムジ ノ チョウカクセイキョウガクハンシャ ニ カンスル シンケイ セイリガクテキ ケントウ

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Abstract

The acoustic startle response (ASR) is a useful neurophysiological measurement in translational research. People with ASD is known to have enhanced auditory perception, however, ASR to weak stimuli in ASD is not investigated well. Thus, the basic profile of ASR, including response to weaker stimuli, might be atypical in ASD, and, close examination of the profile is necessary in order to evaluate ASR. Here, we investigated ASR in 10 Japanese children with ASD and 34 without ASD. The electromyographic activity of the left orbicularis oculi muscle to pulse stimuli of 65 to 115 dB SPL, in increments of 5 dB, was measured to evaluate ASR. Average eyeblink magnitude, average peak startle latency of ASR for each acoustic stimuli intensity was evaluated. Quantitative autistic traits were assessed with the Social Responsive Scale (SRS) to analyze the relationship between startle measures. Magnitude of ASR to weak stimuli (70dB) , was greater in ASD individuals, and Peak startle latency was prolonged in ASD. These startle measures were associated with several subscale scores of SRS. Comprehensive investigation of ASR, including the magnitude of startle responses to weak stimuli and peak startle latency, might increase understanding of the neurophysiological impairments underlying ASD.

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