Thotneosides A, B and C : Potent Antioxidants from Nepalese Crude Drug, Leaves of Aconogonon molle

• Joshi Khem Raj

  Graduate School of Pharmaceutical Sciences, Kumamoto University Program for Leading Graduate Schools “HIGO (Health Life Science: Interdisciplinary and Glocal Oriented) Program,” Kumamoto University

• Devkota Hari Prasad

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Watanabe Takashi

  Research Organization for Regional Alliances, Kochi University of Technology

• Yahara Shoji

  Graduate School of Pharmaceutical Sciences, Kumamoto University Program for Leading Graduate Schools “HIGO (Health Life Science: Interdisciplinary and Glocal Oriented) Program,” Kumamoto University

書誌事項

タイトル別名

• Thotneosides A, B and C: Potent Antioxidants from Nepalese Crude Drug, Leaves of <i>Aconogonon molle</i>

抄録

Three new glycosides: thotneoside A (quercetin 3-O-(6″-O-phenylacetyl)-β-D-galactopyranoside) (1), thotneoside B (quercetin 3-O-(6″-O-phenylacetyl)-β-D-glucopyranoside) (2) and thotneoside C (3-methyl-2-butenoic acid 1-O-β-D-glucopyranoside) (3), together with nine known compounds; quercetin (4), quercetin 3-O-β-D-galactopyranoside (5), quercetin 3-O-(6″-O-galloyl)-β-D-galactopyranoside (6), quercetin 3-O-β-D-galacturonopyranoside (7), quercetin 3-O-β-D-glucuronopyranoside (8), quercetin 3-O-α-L-rhamnopyranoside (9), rutin (10), quercetin 3-O-α-L-arabinopyranoside (11) and 2,4,6-trihydroxyacetophenone 2-O-β-D-glucopyranoside (12) have been isolated from the shade dried leaves of Aconogonon molle, commonly known as “Thotne″ in Nepal. The structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from A. molle and their in vitro antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Quercetin (4) and its glycosides (1–2, 5–11) showed potent free radical scavenging activity.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 62 (2), 191-195, 2014

  公益社団法人 日本薬学会

キーワード

• <i>Aconogonon molle</i>
• thotneoside
• <i>in vitro</i>
• Thotne
• 1,1-diphenyl-2-picrylhydrazyl (DPPH)
• Nepal

詳細情報

• CRID: 1390282679155111168
• NII論文ID: 130003381820
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c13-00748
• COI: 1:STN:280:DC%2BC2c3itFemtg%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 025171870
• PubMed: 24292866
• Web Site: http://id.ndl.go.jp/bib/025171870
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025171870
• Web Site: https://www.jstage.jst.go.jp/article/cpb/62/2/62_c13-00748/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014299697
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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