Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism

• Giamarellos-Bourboulis Evangelos J.

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Spyridaki Aikaterini

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Savva Athina

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Georgitsi Marianna

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Tsaganos Thomas

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Mouktaroudi Maria

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Raftogiannis Maria

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Antonopoulou Anastasia

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Papaziogas Vassilios

  Second Department of Surgery, University of Thessaloniki, Medical School, Greece

• Baziaka Fotini

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Sereti Kalliopi

  Second Department of Internal Medicine, “Sismanogleion” Athens Hospital, Greece

• Christopoulos Petros

  Second Department of Surgery, University of Thessaloniki, Medical School, Greece

• Marioli Androniki

  Second Department of Internal Medicine, “Sismanogleion” Athens Hospital, Greece

• Kanni Theodora

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Maravitsa Panagiota

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Pantelidou Ilianna

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Leventogiannis Konstantinos

  Fourth Department of Internal Medicine, University of Athens, Medical School, Greece

• Tsiaoussis Panagiotis

  Second Department of Surgery, University of Thessaloniki, Medical School, Greece

• Lymberopoulou Korina

  Second Department of Internal Medicine, “Sismanogleion” Athens Hospital, Greece

• Koutelidakis Ioannis M.

  Second Department of Surgery, University of Thessaloniki, Medical School, Greece

抄録

One prospective, open-label, non-randomized study was conducted in 100 patients to define the antipyretic and analgesic effect of a new intravenous formulation of 1 g of paracetamol; 71 received paracetamol for the management of fever and 29 received paracetamol for pain relief after abdominal surgery or for neoplastic pain. Serial follow-up measurements of core temperature and of pain intensity were done for 6 h. Additional rescue medications were recorded for 5 days. Blood was sampled for the measurement of free paracetamol (APAP) and of glucuronide-APAP and N-sulfate-APAP by an HPLC assay. Defervescence, defined as core temperature below or equal to 37.1°C, was achieved in 52 patients (73.2%) within a median time of 3 h. Patients failing to become afebrile with the first dose of paracetamol became afebrile when administered other agents as rescue medications. Analgesia was achieved in 25 patients (86.4%) within a median time of 2 h. Serum levels of glucuronide-APAP were greater among non-responders to paracetamol. The presented results suggest that the intravenous formulation of paracetamol is clinically effective depending on drug metabolism.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 124 (2), 144-152, 2014

  公益社団法人 日本薬理学会

キーワード

• intravenous paracetamol
• fever
• pain
• analgesia

詳細情報

• CRID: 1390001205179158656
• NII論文ID: 130003391475
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.13133fp
• COI: 1:CAS:528:DC%2BC2cXkt1egtrY%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 025296114
• PubMed: 24553403
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025296114
• Web Site: https://www.jstage.jst.go.jp/article/jphs/124/2/124_13133FP/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014299886
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可