Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction

  • Kajikawa Masato
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Nakashima Ayumu
    Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital
  • Maruhashi Tatsuya
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Iwamoto Yumiko
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Iwamoto Akimichi
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Matsumoto Takeshi
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Hidaka Takayuki
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Kihara Yasuki
    Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Chayama Kazuaki
    Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciencies, Hiroshima University
  • Goto Chikara
    Hiroshima International University
  • Taguchi Akira
    Department of Oral and Maxillofacial Radiology, Matsumoto Dental University
  • Noma Kensuke
    Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • Higashi Yukihito
    Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

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Background: Poor oral health is an independent predictor of cardiovascular outcome. Endothelial dysfunction is the initial step of atherosclerosis, resulting in cardiovascular outcomes; but there is no information on the association between oral health and endothelial function. The purpose of this study was to determine the relationships between oral health and endothelial function. Methods and Results: A total of 190 subjects who underwent health examinations (mean age, 57±18 years), including patients with cardiovascular disease, completed a questionnaire on oral health and frequency of tooth brushing, and underwent measurement of vascular function, flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation. The subjects were divided into 2 groups according to frequency of tooth brushing (≥twice/day and <once/day). FMD was significantly lower in the <once/day tooth brushing group as compared to the ≥twice/day tooth brushing group (3.3±2.2% vs. 5.0±3.0%, P<0.001). There was no significant difference in nitroglycerine-induced vasodilation between the 2 groups. On multiple logistic regression analysis, tooth brushing <once/day remained independently associated with low FMD tertile. Conclusions: Poor oral health, that is, decreased frequency of tooth brushing, is associated with endothelial dysfunction.  (Circ J 2014; 78: 950–954)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (4), 950-954, 2014

    一般社団法人 日本循環器学会

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