Ranolazine Attenuates the Enhanced Reverse Na⁺-Ca²⁺ Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes

DOI Web Site Web Site PubMed 被引用文献1件 参考文献47件
  • Wang Xiao-Jing
    Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
  • Wang Lei-Lei
    Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
  • Fu Chen
    Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
  • Zhang Pei-Hua
    Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
  • Wu Ying
    Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
  • Ma Ji-Hua
    Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China

書誌事項

タイトル別名
  • Ranolazine Attenuates the Enhanced Reverse Na<sup>+</sup>-Ca<sup>2+</sup> Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes

この論文をさがす

抄録

Ranolazine (RAN), a novel antianginal agent, inhibits the increased late sodium current (INa.L) under many pathological conditions. In this study, the whole-cell patch-clamp technique was used to explore the effects of RAN on INa.L and reverse Na+/Ca2+ exchange current (INCX) in rabbit ventricular myocytes during hypoxia.Tetrodotoxin (TTX) at 2 μM or RAN at 9 μM decreased significantly INa.L and reverse INCX under normoxia and RAN had no further effects on both currents in the presence of TTX. RAN (3, 6, and 9 μM) attenuated hypoxia-increased INa.L and reverse INCX in a concentration-dependent manner. Hypoxia-increased INa.L and reverse INCX were inhibited by 2 μM TTX, whereas 9 μM RAN applied sequentially did not further decrease both currents. In another group, after both currents were decreased by 9 μM RAN, 2 μM TTX had no further effects in the presence of Ran. In monophasic action potential (MAP) recording, early after-depolarizations (EADs) were suppressed by RAN (9 μM) during hypoxia. In conclusion, RAN decreased reverse INCX by inhibiting INa.L in normoxia, concentration-dependently attenuated the increase of INa.L, which thereby decreased the reverse INCX, and obviously relieved EADs during hypoxia.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (47)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ