Bromopyrrole Alkaloids from a Marine Sponge Agelas sp

• Kusama Taishi

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• Tanaka Naonobu

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• Takahashi-Nakaguchi Azusa

  Medicinal Mycology Research Center, Chiba University

• Gonoi Tohru

  Medicinal Mycology Research Center, Chiba University

• Fromont Jane

  Western Australian Museum

• Kobayashi Jun’ichi

  Graduate School of Pharmaceutical Sciences, Hokkaido University

書誌事項

タイトル別名

• Bromopyrrole Alkaloids from a Marine Sponge <i>Agelas</i> sp.

抄録

Five new bromopyrrole alkaloids, 2-bromokeramadine (1), 2-bromo-9,10-dihydrokeramadine (2), tauroacidins C (3) and D (4), and mukanadin G (5), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1–5 were elucidated on the basis of spectroscopic data and conformational analysis. Mukanadin G (5) has a tricyclic skeleton consisting of a fused tetrahydrobenzaminoimidazole and 2,5-dioxopyrrolidine moieties. Antimicrobial activities of 1–3, and 5 as well as three related known bromopyrrole alkaloids, keramadine (6), tauroacidin A (7), and taurodispacamide A (8) were evaluated.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 62 (5), 499-503, 2014

  公益社団法人 日本薬学会

キーワード

• bromopyrrole alkaloid
• marine sponge
• <i>Agelas</i> sp.

詳細情報

• CRID: 1390001204177145344
• NII論文ID: 130004053787
• NII論文ID: 40020048729
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c14-00077
• COI: 1:STN:280:DC%2BC2cnpsVCiug%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 025419749
• PubMed: 24789935
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025419749
• Web Site: https://www.jstage.jst.go.jp/article/cpb/62/5/62_c14-00077/_pdf
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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