Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants

• Matsuda Hisashi

  Kyoto Pharmaceutical University

• Nakamura Seikou

  Kyoto Pharmaceutical University

• Yoshikawa Masayuki

  Kyoto Pharmaceutical University

抄録

Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPARγ agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii, piperlonguminine and retrofractamide A from the fruit of Piper chaba, and tetramethylkaempferol and pentamethylquercetin from the rhizomes of Kaempferia parviflora, are reviewed.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 37 (6), 884-891, 2014

  公益社団法人 日本薬学会

キーワード

• hydrangenol
• hydrangeic acid
• retrofractamide A
• pentamethylquercetin
• peroxisome proliferator-activated receptor γ (PPARγ) agonist-like compound
• 3T3-L1 cell

詳細情報

• CRID: 1390282679607997184
• NII論文ID: 130004147348
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b14-00037
• COI: 1:STN:280:DC%2BC2cjot1Giug%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 025478777
• PubMed: 24882400
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025478777
• Web Site: https://www.jstage.jst.go.jp/article/bpb/37/6/37_b14-00037/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015049375
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可