Antitumor Activity of Triterpenoid Saponin-Rich Adisia gigantifolia Extract on Human Breast Adenocarcinoma Cells in Vitro and in Vivo

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  • Mu Li-Hua
    Department of Clinical Pharmacology, General Hospital of PLA
  • Bai Lin
    Department of Clinical Pharmacology, General Hospital of PLA
  • Dong Xian-Zhe
    Department of Clinical Pharmacology, General Hospital of PLA
  • Yan Fu-Qin
    General Hospital of Chinese People’s Armed Police Forces
  • Guo Dai-Hong
    Department of Clinical Pharmacology, General Hospital of PLA
  • Zheng Xiao-Li
    Department of Clinical Pharmacology, General Hospital of PLA Tianjin University of TCM
  • Liu Ping
    Department of Clinical Pharmacology, General Hospital of PLA

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  • Antitumor Activity of Triterpenoid Saponin-Rich <i>Adisia gigantifolia</i> Extract on Human Breast Adenocarcinoma Cells <i>in Vitro</i> and <i>in Vivo</i>

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The aim of this study was to explore whether the ethanolic extract of Ardisia gigantifolia rhizomes (AGB-5), a traditional herbal medicine from China, could affect the proliferation of human breast adenocarcinoma (MCF-7) cells in vitro and to explore the antitumor effects of AGB-5 in BALB/c mice engrafted with MCF-7 cells. The results showed that AGB-5 markedly inhibited the proliferation of MCF-7 cells with an IC50 value of 11.89±1.12 µg/mL, increased the S phase and decreased the G2/M phase without influence on G1 phase. MCF-7 cells treated with AGB-5 presented a dose-dependent increase of apoptosis compared with the control group. AGB-5 also significantly increased the activity of caspase-3 and -9 in a dose-dependent manner in MCF-7 cells. Furthermore, in an in vivo model, AGB-5 reduced tumor volume, brought back the red blood cell (RBC) and white blood cell (WBC) count near to normal value, enhanced superoxide dismutase and catalase level of MCF-7 bearing mice. This is the first study to verify the antitumor activity of A. gigantifolia in vivo. The results suggest that AGB-5 may have potential beneficial effects against human breast adenocarcinoma.

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