Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A₂ Levels in Streptozotocin-Induced Diabetic Mice

DOI Web Site Web Site PubMed 被引用文献9件 参考文献7件
  • Taguchi Kumiko
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Hida Mari
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Matsumoto Takayuki
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Ikeuchi-Takahashi Yuri
    Department of Drug Delivery Research, Hoshi University
  • Onishi Hiraku
    Department of Drug Delivery Research, Hoshi University
  • Kobayashi Tsuneo
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

書誌事項

タイトル別名
  • Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A<sub>2</sub> Levels in Streptozotocin-Induced Diabetic Mice

この論文をさがす

抄録

Diabetes is characterized by the development of endothelial dysfunction, which affects both nitric oxide (NO)-mediated relaxation and endothelium-derived contracting factors, associated with vascular oxidative stress. There is a growing body of evidence suggesting that polyphenols have several beneficial effects, such as antioxidant and anti-inflammatory activities. This study investigated whether short-term treatment with polyphenols (chlorogenic acid (CA), morin (MO), resveratrol (RV)) can improve endothelial dysfunction related to diabetes. Aorta reactivity was determined in organ chambers, and we measured NO production and thromboxane B2 (TXB2; a metabolite of TXA2) from aortas in response to acetylcholine (ACh). Streptozotocin (STZ)-induced diabetic mice (16 weeks) were injected with solvent (ethanol, 10% v/v; intraperitoneally (i.p.)), CA (0.03 mmol/kg/d), MO (0.03 mmol/kg/d), and RV (0.03 mmol/kg/d) for 5 d. The ACh-induced endothelium-dependent relaxation was markedly reduced in rings of STZ-induced diabetic mice compared to controls. The treatment with polyphenols (significantly: MO, tendency: CA and RV) for only 5 d improved the NO components of relaxation, but did not normalize ACh-stimulated NO production. However, polyphenol treatment suppressed the ACh-stimulated level of TXB2 in aortas from STZ-induced diabetic mice. Thus, treatment with polyphenols caused basal NO production and a prompt improvement of the endothelial function in diabetic mice, and this may involve the normalization of TXA2 levels, not NO production, under ACh stimulation.

収録刊行物

被引用文献 (9)*注記

もっと見る

参考文献 (7)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ