Peroxisome Proliferator-activated Receptor-γ agonists Prevent Tumor Necrosis Factor-α-mediated Inhibition of FSH-induced Follicle Development and Estradiol Production in A PreantralFollicle Culture System
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- Hara Shuichiro
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan Department of Obstetrics and Gynecology, Social Welfare Organization Saiseikai Imperial Gift Foundation Inc. Yamagata Saisei Hospital, 79-1, Okimachi, Yamagata city, Yamagata 990-8545, Japan
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- Takahashi Toshifumi
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan
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- Igarashi Hideki
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan
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- Amita Mitsuyoshi
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan
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- Matsuo Koki
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan
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- Hasegawa Ayumi
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan
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- Kurachi Hirohisa
- Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan
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Although 60–80% of the women with polycystic ovary syndrome (PCOS) ovulate with clomiphene citrate (CC), the rest are CC-resistant. Recently, the use of insulin-sensitizing agents such as metformin and pioglitazone have been proposed for inducing ovulation in CC-resistant women with PCOS, and we have reported that administration of bezafibrate, a lipid-lowering fibrate, in addition to CC, successfully induced ovulation in CC-resistant women with PCOS and dyslipidemia. Both pioglitazone and bezafibrate are peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists. This paper reviews the evidence for the direct effects of the drugs, which are PPAR-γ agonists, on follicle development and steroidogenesis, collected using an in vitro mouse preantral follicle culture system. We used the in vitro follicle culture system with the addition of tumor necrosis factor-alpha (TNF-α), which plays a role in insulin resistance, as a model for studying follicle development in women with PCOS. TNF-α inhibited FSH-induced follicle development and steroidogenesis in the follicle culture system. Both pioglitazone and bezafibrate prevented TNF-α-mediated inhibition of FSH-induced follicle development and steroidogenesis through the PPAR-γ-stimulating pathway. Our results suggest that insulin-sensitizing drugs, especially PPAR-γ agonists, may directly influence follicle development and steroidogenesis in women with PCOS.
収録刊行物
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- 日本哺乳動物卵子学会誌
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日本哺乳動物卵子学会誌 31 (1), 2-11, 2014
日本卵子学会
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詳細情報 詳細情報について
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- CRID
- 1390282679315454592
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- NII論文ID
- 130004436884
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- NII書誌ID
- AN10548943
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- ISSN
- 13475878
- 13417738
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- NDL書誌ID
- 025509156
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可