Enhancement of Ionization Efficiency Using Zeolite for Imaging Mass Spectrometry of a Drug with Matrix-Assisted Laser Desorption/Ionization
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- Hazama Hisanao
- Graduate School of Engineering, Osaka University
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- Moriguchi Naoki
- Graduate School of Engineering, Osaka University
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- Fujino Tatsuya
- Graduate School of Science and Engineering, Tokyo Metropolitan University
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- Awazu Kunio
- Graduate School of Engineering, Osaka University
Bibliographic Information
- Other Title
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- マトリックス支援レーザー脱離イオン化を用いた薬剤のイメージング質量分析に向けたゼオライトによるイオン化効率の向上
- マトリックス シエン レーザー ダツリ イオンカ オ モチイタ ヤクザイ ノ イメージング シツリョウ ブンセキ ニ ムケタ ゼオライト ニ ヨル イオンカ コウリツ ノ コウジョウ
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Abstract
Imaging mass spectrometry using matrix-assisted laser desorption/ionization has increasingly got attention as a new analysis method of pharmacokinetics to accelerate the drug discovery processes. However, the detection sensitivity has been too low for practical analysis. By mixing zeolite (NaY5.6) with a conventional organic matrix, α-cyano-4-hydroxycinnamic acid (CHCA), the ion signal intensity of a drug, buspirone, at a concentration of 100 ng/mL was enhanced to about 1.6 times compared with that measured using CHCA only. The zeolite matrix enabled the detection of buspirone at a concentration of 0.1 ng/mL. The ion signal intensity of buspirone obtained from a brain section of a mouse administered buspirone was also enhanced to about two times by using the zeolite matrix compared with that measured using CHCA.
Journal
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- IEEJ Transactions on Electronics, Information and Systems
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IEEJ Transactions on Electronics, Information and Systems 134 (5), 657-663, 2014
The Institute of Electrical Engineers of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679584867072
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- NII Article ID
- 130004870035
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- NII Book ID
- AN10065950
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- ISSN
- 13488155
- 03854221
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- NDL BIB ID
- 025529071
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
