Drop-on-demand Patterning of Microtubules by using a Needle Type Micro Dispenser

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To detect disease biomarkers in molecular level in an on-chip format, a precise patterning of functional biomolecule is crucial step of building diagnostic devices. Here, we aim at integrating a microtubule-based fluidic device to detect early state of Alzheimer's disease. Temperature or pressure-sensitive, fragile microtubule can easily depolymerize, so that it cannot be easily patterned with conventional methods, such as inkjet printing, micro contact printing, etc. For this purpose, we performed direct patterning of microtubules in 100-so tiameter by using a needle-type dispenser on fluidic device and their functionality with Kinesin motion was successfully confirmed. Overall, our results indicate that the needle type micro dispenser may pattern even fragile biomaterials in micro scale, and integrated fluidic device is promising for detecting tau protein, which is a biomarker of neurodegenerative diseases.

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